FoldRx

FoldRx is a biotechnology company that specializes in computational protein folding and protein design to accelerate drug discovery and enzyme engineering. The company develops software and services that integrate machine learning, physics-based modeling, and high-performance computing to predict protein structures, design novel proteins, and optimize biotherapeutic candidates.

FoldRx's approach combines data-driven models trained on large structural datasets with physics-based refinement and molecular dynamics simulations. The resulting workflows aim to deliver accurate structure predictions, design proteins with target stability and activity, and enable rapid iteration for lead optimization, while providing interpretable outputs to support experimental validation.

Applications and collaborations: FoldRx works with pharmaceutical companies, academic laboratories, and contract research organizations to apply its technology to target discovery, enzyme engineering, and biosensor development. The company has published research on structure prediction, protein design, and validation methodologies in peer-reviewed journals and participates in industry consortia on computational biology standards.

Challenges and considerations: As with other computational protein design efforts, FoldRx emphasizes the need for experimental validation and reproducibility. Regulatory considerations for therapeutics derived from designed proteins demand rigorous validation, safety assessment, and documentation of computational methods.

Related topics include protein folding, AlphaFold, and protein design.