Farmakometria
Farmakometria, or pharmacometrics, is a scientific discipline that uses mathematical models, statistics, and computational tools to quantify the relationship between drug exposure and pharmacological effect. The goal is to understand how drugs behave in the body (pharmacokinetics) and how those exposures translate into therapeutic or adverse effects (pharmacodynamics) and to use this understanding to optimize dosing.
Core activities include developing population PK/PD models that describe typical behavior and between-subject variability, identifying covariates
Methods and tools: nonlinear mixed-effects modeling, Bayesian estimation, and dose–response modeling are common. Software platforms such
Applications span drug development, regulatory submissions, and clinical practice. In development, pharmacometrics supports dose finding, regimen
Limitations include potential model misspecification, identifiability constraints, and data quality. Robust validation, external data, and transparent