FAZ1

FAZ1, also known as Fascinate-associated gene 1 or more commonly, the Fascin protein, is a gene that encodes a 55 kDa actin-binding protein. This protein plays a crucial role in regulating the actin cytoskeleton, a dynamic network of protein filaments within the cytoplasm of eukaryotic cells that is essential for cell structure, movement, and division. Fascin1 is particularly involved in the formation of actin filopodia, which are thin, dynamic, finger-like protrusions of the cell membrane that are involved in cell migration, cell-cell adhesion, and mechanosensing.

The expression of FAZ1 is particularly notable in certain cell types and during specific developmental processes. It is found at elevated levels in cells that exhibit high migratory activity, such as during embryonic development, wound healing, and immune responses. In cancer biology, Fascin1 has gained significant attention due to its frequent overexpression in various types of tumors. This overexpression is often correlated with increased tumor aggressiveness, metastasis, and poor patient prognosis. Consequently, Fascin1 has emerged as a potential diagnostic marker and a therapeutic target for cancer treatment. Research efforts are ongoing to develop small molecule inhibitors and other strategies to target Fascin1 activity and impede tumor progression.