EyeTrials

EyeTrials is an international, open-access registry and results database for ophthalmology and vision science. It collects trial registrations, protocols, recruitment status, endpoints, and outcomes to help researchers, clinicians, and patients identify eye-related trials and monitor research progress. The platform emphasizes transparency and accessibility.

It covers clinical trials of glaucoma, age-related macular degeneration, diabetic retinopathy, retinal dystrophies, pediatric eye conditions, ocular surface diseases, and emerging therapies such as gene therapy and surgical innovations. EyeTrials uses standardized disease and intervention terminology and supports core outcome sets. Trials may be registered prospectively and report summary results.

Governance is provided by a non-profit consortium of academic medical centers, patient groups, and funding agencies. The registry adheres to ethical guidelines, data privacy laws, and international reporting standards, including ICH-GCP and CONSORT. It collaborates with global registries to promote harmonization and interoperability.

Key features include advanced search and filtering by condition, intervention, phase, location, and status; data export and API access; multilingual support; and a transparency framework for reporting deviations and adverse events.

Impact and reception are mixed. Proponents view EyeTrials as a model for reducing publication bias and duplicative research in ophthalmology, while critics point to ongoing challenges in data completeness, resource requirements, and equitable participation across regions.