EMMPRIN

EMMPRIN, also known as Extracellular Matrix Metalloproteinase Inducer or CD147, is a transmembrane glycoprotein that plays a crucial role in cell signaling and cell-cell adhesion. It is expressed on the surface of various cell types, including immune cells, cancer cells, and endothelial cells.

A primary function of EMMPRIN is its ability to induce the production and secretion of matrix metalloproteinases (MMPs). MMPs are enzymes involved in the breakdown of extracellular matrix, a process essential for tissue remodeling, wound healing, and cell migration. However, aberrant MMP activity, often driven by EMMPRIN, is implicated in pathological conditions such as cancer invasion and metastasis, as well as inflammatory diseases.

EMMPRIN interacts with other cell surface receptors and signaling molecules, contributing to complex cellular processes. It has been investigated for its involvement in angiogenesis, the formation of new blood vessels, which is vital for tumor growth. Furthermore, EMMPRIN's role in immune responses, particularly in T-cell activation and function, is an active area of research.

Due to its involvement in disease progression, EMMPRIN has emerged as a potential therapeutic target. Inhibiting EMMPRIN activity or expression is being explored as a strategy to combat cancer metastasis and other inflammatory conditions. Research continues to elucidate the multifaceted roles of EMMPRIN in normal physiology and disease states.