Dydrogesterone

Dydrogesterone is a synthetic progestogen, a type of medication that mimics the effects of the natural hormone progesterone. It is primarily used to treat a range of gynecological conditions influenced by progesterone deficiency. These conditions include luteal phase defects, which can contribute to infertility and recurrent miscarriages, as well as irregular menstrual cycles, painful menstruation (dysmenorrhea), and endometriosis.

The mechanism of action for dydrogesterone involves its binding to progesterone receptors in the uterus. This binding promotes the development of the uterine lining (endometrium), making it receptive for implantation of a fertilized egg and helping to maintain pregnancy. It also helps to alleviate menstrual pain and reduce the growth of endometrial tissue outside the uterus, which is characteristic of endometriosis. Unlike some other progestogens, dydrogesterone is not known to have androgenic or estrogenic effects, and it does not typically inhibit ovulation.

Dydrogesterone is administered orally. The dosage and duration of treatment depend on the specific condition being managed and are determined by a healthcare professional. Common side effects can include headache, dizziness, nausea, breast tenderness, and irregular vaginal bleeding. It is important for individuals to discuss their medical history and any other medications they are taking with their doctor before starting dydrogesterone, as it may not be suitable for everyone. Contraindications include known or suspected pregnancy (unless prescribed for specific pregnancy support), undiagnosed vaginal bleeding, and certain liver conditions.