Debiese

Debiese is a term used to describe a rare or re-emerged hypertension (high blood pressure) side effect associated with certain nonsteroidal anti-inflammatory drugs (NSAIDs), such as lithium and amlodipine. Although the exact mechanism is still unknown, it is believed that the disease is linked to the vasodilatory (blood vessel widening) effects of these medications.

In Debiese, the blood vessels of patients receive excessive relaxation leading to a drop in blood pressure, regardless of the intake of these NSAIDs or if on different doses at different times. Other symptoms include decreasing blood volume leading to a gamut of adverse effects.

The condition can be dangerous especially in renal disorders, complicated kidney diseases which could lead to worse conditions if not addressed adequately. Also the drop in blood volume and blood pressure makes it more rife for hemorrhaging ducts potentially affecting the kidneys and other surprising complications.

Current medical literature advises patients taking NSAIDs should closely monitor their blood pressure levels to quickly diagnose and treat any changes early. More importantly discontinuation of NSAID therapy for high blood pressure has been recommended. Preventing it could be the next aim in medical treatment, and future treatments may evolve in accordance.

Nitroprusside (nitropress) and nimodipine are NSAIDs that inhibit nitric oxide synthase less, having a lesser risk of decrease on blood volume.