DHAderived

DHAderived is a term used to describe molecules that originate from docosahexaenoic acid (DHA), an omega-3 fatty acid abundant in fish oil and in neural and retinal tissues. In scientific contexts it is used to refer to metabolites and conjugates formed when DHA is enzymatically oxygenated or chemically modified, as well as synthetic derivatives used in research.

Prominent families of DHA-derived molecules include specialized pro-resolving mediators such as resolvins of the D-series (RvD1–RvD6), protectins (e.g., protectin D1), and maresins (MaR1). These compounds are produced via lipoxygenase- and cyclooxygenase-mediated pathways and play roles in resolving inflammation and promoting tissue repair. Another well-studied DHA-derived molecule is synaptamide, N-docosahexaenoylethanolamide, an endocannabinoid-like lipid with reported neurotrophic and neuroprotective effects. In addition, DHA can form various DHA-containing phospholipids and glycerol esters that are considered DHA-derived.

Biologically, DHA-derived molecules are associated with anti-inflammatory actions, immune modulation, synaptic plasticity, and neuronal survival. They are investigated for potential therapeutic roles in neurodegenerative diseases, ocular health, and inflammatory disorders.

Dietary intake of DHA influences tissue levels and the abundance of DHA-derived metabolites. Rich sources include fatty fish and fortified foods. In research contexts, analytic methods such as liquid chromatography–mass spectrometry are used to quantify DHA-derived species in tissues and fluids.

Note: DHAderived is not a universally standardized term; it is used descriptively to denote molecules derived from docosahexaenoic acid. The exact classification varies across studies.