CsrAbinding
CsrAbinding, also known as Cysteine String Protein Alpha (CSPα) binding, refers to the interaction of CSPα with other proteins, particularly SNAREs (Soluble NSF Attachment Protein Receptors), in the context of neurotransmitter release and synaptic vesicle trafficking. CSPα is a member of the cysteine string protein family, which is characterized by a unique cysteine-rich domain that undergoes palmitoylation, a lipid modification that facilitates membrane association.
The primary function of CsrAbinding is to regulate the stability and function of SNARE complexes, which are
CsrAbinding is also involved in the protection of SNAREs from degradation and the regulation of their recycling.
Mutations or dysfunctions in CSPα have been linked to neurodegenerative diseases, including Parkinson's disease and Alzheimer's