Comprimat

Comprimat is a solid dosage form created by compressing an active pharmaceutical ingredient (API) with excipients into a compact unit. It is designed for internal use and is most commonly administered orally, though some forms are intended for sublingual, buccal, or chewable administration.

Comprimats come in several forms and coatings. Uncoated tablets may be swallowed whole; film-coated and sugar-coated tablets improve taste and protection from stomach acid. Modified-release variants include immediate-release, delayed-release (enteric-coated), and sustained-release formulations. There are also effervescent tablets and disintegrating or orally dissolving tablets.

Composition and manufacturing: Typical comprimats combine API with excipients such as binders (povidone, hydroxypropyl cellulose), fillers (lactose, microcrystalline cellulose), disintegrants (croscarmellose sodium, starch), and lubricants (magnesium stearate). They are produced by compression on a tablet press, with quality control assessing weight uniformity, hardness, friability, disintegration time, and dissolution. Coatings and additives influence stability, taste, and drug release profile.

Regulatory and safety: Comprimats are regulated medicinal products and manufactured under good manufacturing practices. They must meet pharmacopoeial specifications for identity, purity, potency, and dosage uniformity, with proper labeling, lot tracing, and expiration dating.

Usage and storage: Dosing instructions depend on the specific product. Some tablets should not be split, crushed, or chewed, especially modified-release forms. Store in a dry place at recommended temperatures, protected from light, and out of reach of children.

Etymology: The term comprimat is used in several languages, including Romanian and Dutch, for a solid dosage form; it derives from Latin comprimere “to press together.”