Chloromasare

Chloromasare, also known as extramedullary myeloid tumors or granulocytic sarcomas, are localized collections of myeloid blast cells that occur outside the bone marrow. These tumors can arise at various sites, including the skin, lymph nodes, soft tissues, and even the central nervous system. While the exact cause is not fully understood, chloromasare are most commonly associated with myeloproliferative disorders, particularly chronic myeloid leukemia (CML) and acute myeloid leukemia (AML).

The appearance of chloromasare can vary depending on the location and the underlying myeloid disorder. They often present as firm, non-tender masses. Cutaneous chloromasare, for example, may appear as bluish-green nodules or plaques, which is the origin of the term "chloro" (green). However, the color is not always present and can depend on the amount of myeloperoxidase within the blast cells.

Diagnosis typically involves a biopsy of the affected tissue, followed by histological examination and immunophenotyping to confirm the presence of myeloid blasts. Treatment strategies are guided by the underlying myeloid malignancy and may include chemotherapy, radiation therapy, or surgical excision if the tumor is localized and causing significant symptoms. The prognosis for patients with chloromasare is generally dependent on the aggressiveness of the associated hematologic disorder.