Cellerangivelse

Cellerangivelse refers to the labeling or tagging of cells to identify, track, or characterize them in research and clinical contexts. The goal is to make cells detectable by analytical tools such as microscopes, flow cytometers, or imaging systems. Labeling can be achieved through various approaches, including fluorescent dyes, fluorescent or luminescent proteins, antibody-based tagging of cell surface markers, and genetic reporters or DNA barcodes. Labels may be synthetic, such as dyes, or biological, such as expressed proteins. In some cases, metabolic labeling or click-chemistry approaches are used to incorporate labels into cellular components.

Common applications include tracking cell migration and fate during development or disease progression, monitoring the behavior of engineered cells in cell therapies, sorting and isolating populations by flow cytometry, and enabling lineage tracing in longitudinal studies. In vivo imaging and noninvasive modalities like PET or SPECT can use radioactive or reporter-based labels to visualize cellular distribution in living organisms.

Considerations in cell labeling include effects on cell viability and function, label stability and dilution with cell division, potential off-target labeling, and compatibility with downstream assays. Controls and appropriate validation are essential to interpret labeling data accurately.

Overall, cell labeling and tracking is a foundational technique across cell biology, immunology, stem cell research, and regenerative medicine, providing a means to observe cellular dynamics in complex biological systems.