CYPcentric
CYPcentric is a term that refers to a paradigm or approach that places Cytochrome P450 enzymes at the center of focus for drug metabolism studies. Cytochrome P450, or CYP, enzymes are a superfamily of heme-containing proteins that play a crucial role in the metabolism of a vast array of endogenous and exogenous compounds, including drugs. Understanding the involvement of specific CYP isoforms in drug metabolism is essential for predicting drug-drug interactions, determining optimal drug dosages, and identifying potential toxicity.
A CYPcentric approach involves systematic investigation into which CYP enzymes are responsible for the metabolic clearance
This detailed understanding allows for the development of more predictable pharmacokinetic profiles for new drug candidates.