CYP3A45

CYP3A45 is not a gene name currently recognized in major human gene databases. As of the latest standard catalogs (such as HGNC, Ensembl, and NCBI Gene), there is no confirmed human gene designated CYP3A45. It may represent a misannotation, a predicted or noncanonical sequence, or a designation used in studies of non-human species. When encountered, the context and species should be verified against authoritative nomenclature resources.

In humans, the cytochrome P450 3A (CYP3A) subfamily comprises several well-established genes: CYP3A4, CYP3A5, CYP3A7, and CYP3A43. These enzymes are primarily expressed in the liver and intestine and play a major role in the oxidative metabolism of a wide range of drugs and endogenous compounds. CYP3A4 is the most abundant and catalytically versatile member, while CYP3A5 expression is polymorphic and influences aspects of drug clearance in individuals. CYP3A7 is predominantly expressed in fetal tissues, and CYP3A43 is less extensively expressed and its contribution varies among individuals.

Functional features common to the CYP3A enzymes include broad substrate specificity and regulation by xenobiotic receptors such as the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR). Genetic variation and regulatory factors in the CYP3A cluster contribute to interindividual differences in drug metabolism, drug interactions, and response to therapy.

If CYP3A45 appears in literature, it should be treated with caution until its species context and orthology are clarified, and cross-referenced with established CYP3A gene nomenclature. See also: CYP3A subfamily, cytochrome P450, drug metabolism.