COCH2F

COCH2F is a fluoromethyl ether with the molecular formula C2H5FO. Its structure can be described as a methyl group linked to an oxygen atom, which in turn is bonded to a fluoromethyl group, giving the name fluoromethyl methyl ether. In SMILES notation it is written as COCH2F. This compound is an organofluorine ether and is used as a reagent in organic synthesis to introduce fluoromethyl groups.

Molecular properties and typical description in the literature are limited, but COCH2F is generally regarded as a volatile, reactive ether. It has a relatively low molecular weight of about 64.06 g/mol and is soluble in some organic solvents. Exact physical state (gas or liquid) at room temperature can depend on pressure and purity; many fluorinated ethers are volatile with low boiling points.

Synthesis and applications: COCH2F can be prepared through methods that generate fluoromethyl ethers, often by alkylation of a suitable alkoxide with a fluoromethylating electrophile or from fluoromethyl-containing precursors under appropriate conditions. In organic synthesis, fluoromethyl ethers serve as intermediates for introducing the fluoromethyl (CH2F) moiety, and can be used to prepare more complex fluorinated compounds or as precursors to other fluorinated functionalities.

Safety and handling: As a fluorinated ether, COCH2F is typically handled under dry, inert conditions. It is generally expected to be a volatile, potentially irritant and hazardous chemical, and may pose risks if inhaled, ingested, or absorbed through the skin. It should be stored away from moisture and oxidizers, with safety data sheets consulted for detailed hazards and handling procedures.