CDKdriven
CDKdriven is a term used in biology to describe cellular processes, pathways, or states that are primarily regulated by cyclin-dependent kinases (CDKs). It denotes systems in which CDK activity is the dominant driver of progression, rather than other signaling inputs. The concept appears in cell biology, cancer research, and developmental biology to emphasize the central role of CDKs in controlling proliferation and related functions.
CDKs are a family of serine/threonine kinases that regulate key cellular steps. CDK4/6 control early cell cycle
The term is often applied to cancer biology, where elevated CDK activity—due to loss of tumor suppressors
Therapeutically, CDKdriven cancers may respond to CDK inhibitors, notably selective CDK4/6 inhibitors such as palbociclib, ribociclib,