CD15Lewis

CD15Lewis is a blood group antigen belonging to the Lewis blood group system. It is a carbohydrate epitope expressed on the surface of certain cells, including red blood cells and white blood cells. The CD15Lewis antigen is a trisaccharide composed of fucose, N-acetylglucosamine, and galactose. It is closely related to the more commonly known CD15 (Lewis x) antigen but differs in the linkage of the terminal fucose residue.

The presence or absence of CD15Lewis on an individual's red blood cells is determined by genetic factors and is inherited. Unlike some other blood group antigens, CD15Lewis is not typically associated with severe transfusion reactions. However, it can be relevant in certain clinical situations, such as in the investigation of unexplained hemolytic transfusion reactions or in neonatal alloimmune thrombocytopenia. Research into CD15Lewis is ongoing to further understand its role in immunology and potential clinical implications. It is important to distinguish CD15Lewis from other CD15 variants to ensure accurate blood typing and serological interpretation.