CAPZA2

CAPZA2 is a protein that in humans is encoded by the CAPZA2 gene. This gene is a member of the actin-related protein 2 (Arp2) family and is specifically related to the actin-associated protein 2 (CAPZA2) family. The CAPZA2 protein is localized to the cytoplasm and interacts with beta actin filaments, facilitating actin muscle contraction.

Research has shown that CAPZA2 plays a crucial role in actin-based cytoskeleton dynamics. The mutated form of this gene has been associated with an autosomal recessive progressive external ophthalmoplegia and mitotic instability due to RNA mutations and unfolded protein response. The CAPZA2 gene is also linked to higher-order neuronal filaments within the central nervous system and provides robust survival, activation signals, and focal lamp fused cardiomyocytes expression regulation machinery.

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The identification of the CAPZA2 gene has contributed significantly to the understanding of its function and its role in cellular processes. The CAPZA2 protein is vital in many cellular processes.