CAH

CAH is an acronym that can refer to several topics, depending on context. The two widely recognized uses are congenital adrenal hyperplasia, a medical condition, and Cards Against Humanity, a party game.

Congenital adrenal hyperplasia (CAH) comprises inherited disorders affecting adrenal steroid production, most commonly due to 21-hydroxylase deficiency. This impairs cortisol synthesis and often aldosterone production, leading to excess ACTH, adrenal hyperplasia, and increased adrenal androgens. Symptoms vary by form: classic CAH can cause salt-wasting and virilization in infancy; milder nonclassic CAH may present later with signs of androgen excess such as early puberty or hirsutism. Diagnosis commonly relies on elevated 17-hydroxyprogesterone levels and genetic testing; newborn screening in many regions helps early detection. Treatment involves lifelong glucocorticoid replacement to suppress ACTH, with mineralocorticoids added for salt-wasting disease; management includes regular monitoring of growth, electrolytes, puberty, and bone health, and often a consultation with an endocrinologist.

Cards Against Humanity (CAH) is a satirical party game released in 2010. Players complete fill-in-the-blank statements by playing white answer cards that are paired with a black question or prompt card. A rotating judge selects the funniest or most fitting combination, and the player who submitted the winning white card earns a point. The game is designed for adults and is known for its irreverent humor; it has expanded with numerous expansion packs, digital editions, and charitable campaigns that donate proceeds to various causes. It has also faced criticism for content that some players find offensive or exclusionary, prompting discussions about humor, inclusivity, and taste.

In other contexts, CAH is used as an acronym for other organizations, concepts, or terms depending on the field; readers should consult context to determine the intended meaning.