C4komplement

C4komplement, also known as C4 and component 4, is a protein that plays a crucial role in the complement system, a part of the immune system. It is a glycated protein found in the blood plasma of many mammals, including humans.

C4komplement is synthesized in the liver and released into the bloodstream, where it circulates as a large protein complex. Its primary function is to assist in the complement system's innate immune response, helping to fight off pathogens such as bacteria and viruses. C4 komplement binds to antigens, a process that enables the activation of the complement cascade. This leads to the destruction of pathogenic cells, through mechanisms such as membrane attack complex (MAC) formation or opsonization.

C4komplement is a key player in autoimmune diseases, especially those related to the immune system. An imbalance in its levels or function has been linked to genetic and acquired disorders. Some diseases associated with C4komplement dysfunction include systemic lupus erythematosus (SLE) and other conditions affecting the immune system.

Research has also found associations between C4komplement genetic variants and certain conditions, such as major depressive disorder and schizophrenia. Some studies indicate a possible role of C4 in the modulation of cytokine production and immune system homeostasis, underscoring its role in broader physiological processes.

Genetic variations in the C4 komplement gene have been identified as risk factors for certain conditions. Re-evaluation of its significance in current research has led to increased understanding of the relationships between this protein and complex immune-related diseases.