Biarylowane

Biarylowane is a term used in organic chemistry to describe the process or result of forming a biaryl compound. A biaryl is a molecule containing two aryl (aromatic ring) groups that are directly bonded to each other. This direct carbon-carbon bond between two aromatic systems is the defining characteristic of a biaryl. The formation of biaryls is a significant area of research and application in synthetic organic chemistry due to their prevalence in natural products, pharmaceuticals, agrochemicals, and advanced materials.

The synthesis of biaryl compounds often involves cross-coupling reactions, where two different aryl precursors are joined together. Prominent examples of such reactions include Suzuki-Miyaura coupling, Stille coupling, Heck coupling, and Ullmann reaction, many of which are catalyzed by transition metals like palladium or copper. These methodologies allow for the controlled formation of the carbon-carbon bond between the aromatic rings, often with high yields and selectivity. The electronic and steric properties of the aryl rings can be varied extensively, leading to a vast array of potential biaryl structures. The development of efficient and selective biarylowanie methods has been crucial for the construction of complex organic molecules and for exploring new chemical space.