BT491

BT491 is a human follicular lymphoma cell line. It was established from a biopsy of a patient with diffuse, aggressive, intermediate-grade follicular lymphoma. The cell line is characterized by its B-cell origin and expression of surface markers typical of follicular lymphoma. BT491 cells are often used in research to study the biology and pathogenesis of follicular lymphoma, a type of non-Hodgkin lymphoma.

Researchers utilize BT491 to investigate various aspects of follicular lymphoma, including its growth patterns, genetic alterations, and response to potential therapeutic agents. The cell line has been instrumental in understanding the molecular mechanisms driving the disease and in the preclinical evaluation of novel drug candidates. Its continuous availability in laboratory settings allows for reproducible experiments and contributes to the advancement of knowledge in lymphoma research. Studies involving BT491 have explored signaling pathways, apoptosis, and drug resistance relevant to this specific lymphoid malignancy.