BRCC36containing

BRCC36-containing refers to protein assemblies that include BRCC36, also known as BRCC3, a zinc-dependent deubiquitinase that acts on ubiquitin chains. BRCC36-containing complexes play a role in modulating ubiquitin signaling in cellular responses to DNA damage and immune stimuli. The term highlights the catalytic core provided by BRCC36 within larger protein assemblies rather than a single protein.

BRCC36 is a member of the JAMM/MPN+ metalloprotease family and removes K63-linked polyubiquitin chains from substrates. In humans, the BRCC36 gene is BRCC3. Through its deubiquitinase activity, BRCC36 edits ubiquitin signals at sites of cellular stress, influencing the recruitment and activity of other repair or signaling factors within the complex.

Two canonical BRCC36-containing complexes are the BRCA1-A complex and the BRISC complex. The BRCA1-A complex is primarily nuclear and participates in the DNA damage response by modulating BRCA1 function at double-strand breaks; BRCC36’s activity within this complex helps regulate the ubiquitin landscape around damaged chromatin and impacts repair factor recruitment. The BRISC complex is cytoplasmic and is implicated in immune signaling and receptor trafficking, coordinating deubiquitination events that affect signaling pathways in the innate immune response. Both complexes share BRCC36 as the catalytic subunit, but differ in their partner proteins and cellular roles.

In research contexts, BRCC36-containing complexes are studied for their roles in DNA repair efficiency and immune signaling, with ongoing interest in how BRCC36-related deubiquitination influences cancer biology and responses to DNA-damaging therapies.