BRCC36related

BRCC36related is a term used in genetics, molecular biology, and bioinformatics to denote topics, data sets, and literature linked to BRCC36, also known as BRCC3. BRCC36 is a catalytic subunit of BRCA1-A-type protein complexes that localize to sites of DNA double-strand breaks. It is a zinc-dependent metalloenzyme belonging to the JAMM/MPN+ family and functions as a deubiquitinase that cleaves Lys63-linked polyubiquitin chains, counteracting ubiquitination events carried out by E3 ligases during DNA damage signaling. Through its association with BRCA1-A components such as RAP80 and ABRAXAS, BRCC36 helps regulate the recruitment and retention of BRCA1 and other repair factors at damaged chromatin, influencing the choice between repair pathways and the efficiency of homologous recombination.

Biological and clinical relevance: Dysregulation of BRCC36-related pathways can affect DNA repair fidelity and cell cycle checkpoints. Altered BRCC36 expression or mutations have been examined in cancer biology and may impact tumorigenesis, sensitivity to DNA-damaging therapies, and prognosis. Research in this area also investigates interactions with other deubiquitinases and components of ubiquitin signaling.

In research and databases, BRCC36related appears as a topic tag or category in literature databases, genome annotations, and pathway resources, used to organize studies focusing on the BRCA1-A complex, DNA damage response, and ubiquitin signaling.

See also: BRCA1-A complex; BRCC36/BRCC3; RAP80; ABRAXAS; DNA damage response; ubiquitin signaling.