Autoinhibition
Autoinhibition is a regulatory strategy in which a protein's own regions restrain its activity in the absence of a signal. Many enzymes and signaling proteins contain an autoinhibitory domain (AID) or a pseudosubstrate motif that binds to the active site or otherwise blocks substrate access, keeping the protein in a low-activity state until the constraint is relieved.
The inhibition is often intramolecular and can be relieved by conformational changes triggered by ligand binding,
Examples include Src family kinases, which are held inactive by a C-terminal tail and regulatory domains and
Autoinhibition allows tight spatial and temporal control of activity and rapid response to signals. Dysregulation can