AntiGAD
Anti-GAD refers to autoantibodies against glutamic acid decarboxylase, an enzyme that converts glutamate to gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system. There are two isoforms, GAD65 and GAD67, with most clinically relevant autoantibodies directed against GAD65.
Anti-GAD65 antibodies are most commonly associated with autoimmune type 1 diabetes mellitus and with autoimmune neurological
Diagnosis typically involves detection of anti-GAD antibodies in serum, and occasionally cerebrospinal fluid, by immunoassay methods
Management depends on the associated condition. In type 1 diabetes, standard insulin-based therapy is used and