ACBD4

ACBD4 is a protein-coding gene in humans that encodes acyl-CoA binding domain containing 4, a member of the acyl-CoA binding domain-containing (ACBD) protein family. Proteins in this family share an acyl-CoA binding domain and are implicated in intracellular lipid handling. The ACBD4 protein is predicted to contain a conserved acyl-CoA binding motif and, based on family homology, may bind long-chain acyl-CoA esters and participate in fatty acid metabolism or lipid trafficking. The exact subcellular localization and physiological role of ACBD4 remain incompletely characterized; some ACBD family members associate with membranes or organelles such as peroxisomes or mitochondria, but the localization of ACBD4 has not been definitively established.

ACBD4 is conserved across vertebrates and is catalogued in major genome databases such as Ensembl and NCBI. Expression data suggest the gene is expressed in multiple tissues, though detailed tissue-specific expression patterns and regulatory controls are not fully mapped. As with other ACBD family members, ACBD4 is expected to contribute to cellular lipid homeostasis, but direct functional evidence for ACBD4-specific activities is limited and requires further study.

Clinical significance for ACBD4 remains unclear, with no well-established disease associations reported in the major public databases. Ongoing research aims to clarify its precise function, substrates, and interactions within lipid metabolism and intracellular fatty acid transport.