6881280

6881280 is the Entrez Gene identifier assigned by the National Center for Biotechnology Information to a protein‑coding gene in the species Homo sapiens. The gene encodes a nuclear protein that functions as a transcriptional regulator involved in cell cycle control and embryonic development. Chromosomal mapping places the gene on chromosome 2, at the cytogenetic band 2p24.3. The gene transcript produces a protein of approximately 350 amino acids that contains a LIM‑type double zinc finger motif, a domain commonly implicated in protein‑protein interactions and chromatin remodeling. Functional studies indicate that the protein participates in the regulation of genes critical for mesoderm formation and is necessary for proper vascular development during early embryogenesis. Aberrant expression of the gene has been observed in certain human cancers, where it may act as either a tumor suppressor or an oncogenic driver depending on the cellular context. The gene’s promoter region contains several conserved binding sites for transcription factors that are responsive to developmental signals such as Wnt and Hedgehog pathways. Microarray and RNA‑seq analyses have documented high levels of expression in the developing heart and adrenal gland, with lower expression in adult tissues. The gene is highly conserved in mammalian species, and orthologs have been identified in mouse, rat, and cow, where similar developmental roles have been reported. To date, no specific knockout mouse model has been described, but conditional alleles are being developed to assess the gene’s function in vivo. The 6881280 identifier is used in genomic databases, literature, and high-throughput functional screening assays to refer unambiguously to this gene.