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5HT7

5-HT7, or 5-hydroxytryptamine 7 receptor, is a serotonin receptor belonging to the G protein-coupled receptor (GPCR) family. It couples primarily to Gs proteins, activating adenylate cyclase and increasing intracellular cyclic AMP to influence neuronal excitability and synaptic transmission.

Distribution and function: In the brain, 5-HT7 receptors are expressed in regions including the thalamus, hypothalamus,

Pharmacology: The receptor has selective ligands used in research. Antagonists such as SB-269970 are commonly used

Clinical relevance: Altered 5-HT7 signaling has been implicated in preclinical models of mood disorders, anxiety, and

hippocampus,
and
cortex,
with
additional
presence
in
the
spinal
cord
and
some
peripheral
tissues.
Through
its
signaling,
5-HT7
is
linked
to
regulation
of
circadian
rhythms
and
sleep,
learning
and
memory,
mood
regulation,
and
neurodevelopment.
It
is
thought
to
modulate
cortical
and
thalamic
circuits
that
contribute
to
information
processing
and
arousal.
to
study
5-HT7
function,
while
agonists
like
LP-211
and
AS-19
activate
5-HT7
signaling.
Pharmacological
manipulation
of
5-HT7
signaling
can
influence
sleep-wake
patterns,
cognition,
and
mood
in
animal
models.
schizophrenia-like
phenotypes.
The
receptor
is
regarded
as
a
potential
target
for
antidepressant
or
pro-cognitive
therapies,
but
no
5-HT7-targeted
medicines
have
been
approved
for
clinical
use.
Research
continues
to
clarify
the
receptor’s
roles
in
physiology
and
its
potential
as
a
therapeutic
target.