2OmRNA
2OmRNA refers to a chemically modified form of ribonucleic acid in which the 2' hydroxyl group of the ribose sugar is replaced by a methoxy group, a modification more formally known as 2'-O-methyl RNA or 2'-OMeRNA. This modification is commonly introduced at one or more positions during solid-phase synthesis using 2'-O-methyl phosphoramidites, allowing researchers to tailor the properties of the RNA molecule for specific applications. 2OmRNA is not typically found in natural transcripts but is widely used in synthetic oligonucleotides.
The 2'-O-methyl modification has several notable effects on RNA chemistry. It increases resistance to nucleases, enhancing
Common uses of 2OmRNA include research reagents for stabilizing RNA duplexes, antisense oligonucleotides, and certain small