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2Omethylated

2O-methylated refers to a chemical modification involving the addition of a methyl group (-CH3) to the oxygen atom (O) within a molecule. This type of methylation is common in various biological and chemical processes, influencing the stability, activity, and solubility of compounds.

In biological systems, 2O-methylation often occurs on nucleosides, such as guanosine or adenosine, forming methylated derivatives.

Chemically, 2O-methylation can be achieved through specific methyltransferase enzymes in biological contexts or chemical methylation reactions

The term "2O-methylated" is used broadly across disciplines to describe molecules where methylation occurs at the

Understanding 2O-methylation is important in fields like epigenetics, pharmacology, and biochemistry, where such modifications can significantly

These
modifications
are
critical
in
the
regulation
of
gene
expression,
RNA
stability,
and
the
function
of
various
biomolecules.
For
instance,
2O-methylation
of
ribose
in
RNA
molecules
can
impact
the
molecule’s
structure
and
interactions,
thereby
affecting
its
biological
activity.
in
laboratories.
This
modification
is
exploited
in
drug
development
and
molecular
biology
to
alter
the
properties
of
compounds,
such
as
increasing
lipophilicity
or
protecting
against
enzymatic
degradation.
oxygen
atom
attached
to
the
second
position
(or
other
specified
positions)
of
a
core
structure.
It
is
distinguished
from
other
methylation
patterns
by
the
specific
location
of
the
methyl
group,
which
influences
the
molecule’s
three-dimensional
conformation
and
reactivity.
alter
molecular
function
and
biological
pathways.