11q133

11q133 refers to the cytogenetic band on the long arm of chromosome 11, designated 11q13.3. In standard human genome assemblies, this region contains several genes, including CCND1 (cyclin D1), FGF3, FGF4, ORAOV1, and PPFIA1. The content of the band may vary slightly with genome builds, but CCND1 is a defining gene for this locus. Note that the standard cytogenetic designation is 11q13.3; “11q133” is a nonstandard shorthand sometimes encountered in informal contexts.

Clinical significance of this locus arises from its propensity for copy number alterations in cancer. Amplification of 11q13.3 is a common event in various carcinomas and is associated with overexpression of CCND1 and neighboring genes, contributing to cell cycle progression and tumor growth. In hematologic malignancies, the translocation t(11;14)(q13;q32) places CCND1 under regulatory elements of the immunoglobulin heavy chain locus, causing cyclin D1 overexpression in mantle cell lymphoma.

Detection and research methods used to study 11q13.3 alterations include fluorescence in situ hybridization (FISH), array comparative genomic hybridization (array CGH), and next-generation sequencing. These tools help identify copy number gains, amplifications, and structural rearrangements within the region, informing both diagnostic and research contexts.

The 11q13.3 region is widely studied as part of the 11q13 amplicon and remains a focus for understanding tumor biology and identifying potential therapeutic targets.