111trifluoro2propanol

1,1,1-Trifluoro-2-propanol, also known as TFIP or $\alpha$,$\alpha$,$\alpha$-Trifluoro-isopropanol, is a fluorinated alcohol with the chemical formula $\text{C}_3\text{H}_5\text{F}_3\text{O}$. It is a colorless liquid at room temperature with a distinct odor. TFIP is notable for its strong hydrogen-bond donating ability and its relatively high polarity, which influences its solvent properties.

This compound is often used as a solvent in organic chemistry research and industrial applications. Its unique properties make it suitable for dissolving a range of substances, including polymers and peptides, which may be poorly soluble in common organic solvents. TFIP can also act as a co-solvent to modify the properties of other solvent systems.

In terms of its chemical reactivity, TFIP exhibits properties characteristic of alcohols, such as the ability to undergo esterification and etherification. The presence of the trifluoromethyl group significantly impacts its electronic and steric properties, influencing reaction rates and selectivity.

The synthesis of 1,1,1-trifluoro-2-propanol typically involves the reduction of trifluoroacetone or related trifluoromethylated carbonyl compounds. Its production and use are subject to safety considerations due to its chemical nature, and appropriate handling procedures are necessary. TFIP finds applications in areas such as materials science and medicinal chemistry.