alphaalphaalphaTrifluoroisopropanol

Trifluoroisopropanol, also known as 2,2,2-trifluoroisopropanol or TFIP, is a fluorinated alcohol with the chemical formula C3H5F3O. It is a colorless liquid with a characteristic odor. TFIP is miscible with water and many organic solvents.

The unique properties of TFIP are attributed to the strong electron-withdrawing effect of the trifluoromethyl group. This group significantly increases the acidity of the hydroxyl proton compared to isopropanol, making TFIP a more potent hydrogen bond donor. This enhanced hydrogen bonding capability influences its solvent properties and reactivity.

TFIP finds applications as a solvent in organic synthesis, particularly for dissolving polymers and peptides that are poorly soluble in common solvents. Its ability to stabilize helical structures in peptides has made it a valuable tool in biochemical research. Additionally, TFIP can serve as a reagent or a precursor in the synthesis of other fluorinated organic compounds. The safety profile of TFIP includes considerations for its potential irritancy and the need for proper handling procedures.