vibratingmesh

Vibrating mesh, in the context of aerosol generation and inhalation therapy, refers to a technology that uses a perforated membrane driven to vibrate at high frequency to create aerosols. The membrane contains microscopic pores and is typically actuated by a piezoelectric element. When liquid medication is delivered to the mesh, the oscillation pushes the liquid through the pores, forming a fine spray that can be inhaled. Droplet sizes are generally in the 1 to 5 micrometer range, enabling potential deep lung deposition and efficient drug delivery.

Design and operation: The core component is a microfabricated membrane with an array of tiny pores. A piezoelectric or other actuator induces high-frequency vibration of the membrane. Liquid is drawn to the mesh by capillary action and is continuously fed to the surface. The aerosol is produced as liquid passes through the pores and is emitted from the device for inhalation. The approach tends to be compact and relatively energy-efficient, allowing portable devices for home or clinical use.

Applications: The technology is primarily used for inhalation therapy, delivering bronchodilators, corticosteroids, antibiotics, and other medications to patients with asthma, chronic obstructive pulmonary disease, and cystic fibrosis. It is also employed in research settings to study pulmonary drug delivery and, in some cases, for other controlled spray applications where fine aerosols are desired.

Advantages and limitations: Advantages include a high fraction of fine particles, reduced drug waste, quieter operation, and smaller device size compared with traditional jet nebulizers. Limitations can include sensitivity to formulation properties (such as viscosity and particulates), potential for pore clogging, and higher upfront device costs and maintenance requirements.

History: The vibrating mesh approach emerged in the late 20th to early 21st century and has since been adopted by multiple manufacturers as a compact alternative to conventional nebulization methods.