tüdfibrosis
Tüdfibrosis is a rare, chronic fibrotic disorder characterized by progressive replacement of normal tissue with dense extracellular matrix, predominantly collagen, in one or more organ systems. The condition can affect the lungs, liver, skin, kidneys, and occasionally other tissues, leading to gradual loss of function and, in advanced cases, organ failure. Onset is often insidious and symptoms depend on the organs involved.
Clinical features vary but may include shortness of breath and dry cough if the lungs are affected,
The cause is not fully understood and is considered multifactorial. Possible contributors include immune-mediated inflammation, genetic
Pathophysiology involves activation of resident fibroblasts and transformation into myofibroblasts, resulting in excessive deposition of collagen
Diagnosis relies on clinical assessment, imaging, and histopathology. High-resolution imaging and noninvasive measures of tissue stiffness
Management focuses on slowing progression, alleviating symptoms, and treating affected organs. No universally effective cure exists;