transregulatoren
Transregulatoren is a term used in genetics to denote regulatory factors that influence gene expression from a genomic location different from the gene they regulate (trans-acting regulators). These regulators act in trans, whereas cis-regulatory elements such as promoters and enhancers regulate nearby or adjoining sequences on the same DNA molecule. Transregulatoren include transcription factors, coactivators and corepressors that interact with the transcriptional machinery, as well as certain non-coding RNAs that modulate chromatin states or mRNA stability at distant loci.
In practice, trans-regulators affect multiple target genes and contribute to gene regulatory networks that coordinate development,
Studying transregulatoren involves genome-wide and molecular approaches. ChIP-sequencing identifies binding sites, while transcriptome analyses and expression
Terminology varies by language, with trans-acting regulators and transregulatoren often used interchangeably with transcription factors or