transferrina
Transferrin is a secreted glycoprotein produced mainly by the liver and circulating in blood plasma. It is the principal iron-transport protein in humans, binding ferric iron (Fe3+) at two high-affinity sites per molecule and delivering iron to cells throughout the body. In its iron-free form (apo-transferrin) it circulates until it binds iron, forming holo-transferrin.
Each transferrin molecule has two lobes, and each lobe can bind one Fe3+ ion in the presence
Regulation and physiology: transferrin synthesis is influenced by iron status, nutritional state, and inflammatory signals; it
Clinical relevance: abnormal transferrin levels or saturation are used in iron studies to diagnose iron deficiency,