tissuepermeable
Tissuepermeable is a descriptor used to characterize substances that can diffuse through and permeate biological tissues. In this sense, a tissuepermeable compound is capable of moving from blood vessels into the surrounding tissue matrix and across cellular barriers within a tissue to reach sites of action or exposure. This concept is distinct from simple cellular permeability, which focuses on crossing individual cell membranes; tissue permeability encompasses movement through the extracellular matrix, intercellular spaces, and barrier structures within a tissue.
The extent of tissue permeability depends on several factors. Physicochemical properties of the substance—such as molecular
Assessment and terminology: tissue permeability is commonly evaluated through in vitro or ex vivo methods, such
Applications and relevance: the concept is central to pharmacology, toxicology, and drug delivery, informing the design