thrombinbased
Thrombinbased refers to materials, products, or formulations that derive their hemostatic or adhesive properties from thrombin, a serine protease central to the coagulation cascade. In clinical and research contexts, thrombin is used to convert fibrinogen to fibrin, forming a clot, and to activate platelets and other coagulation factors. Thrombin-based preparations are typically applied topically at a wound or surgical site and may include thrombin alone or in combination with fibrinogen and other components to produce a fibrin sealant or adhesive.
Common thrombin-based products include recombinant human thrombin preparations used as topical hemostats, and plasma- or human-derived
Applications include use to control surgical bleeding in cardiac, vascular, hepatic, orthopedic, and neurosurgical procedures, as
Safety and regulation considerations encompass potential risks such as hypersensitivity to thrombin or additives, infection or
Research and development avenues include thrombin-based hydrogels and adhesives for tissue engineering, controlled-release formulations, and combinations