thioredoxinjärjestelmässä
The thioredoxin system is a vital cellular defense mechanism found in all living organisms, responsible for maintaining the cell's redox balance. It comprises two main components: thioredoxin, a small protein with a catalytic active site containing two cysteine residues, and thioredoxin reductase, an enzyme that regenerates the reduced form of thioredoxin. The thioredoxin system plays a crucial role in reducing disulfide bonds, which are formed when two cysteine residues in proteins become oxidized. This reduction is essential for the proper folding and function of many proteins, including enzymes involved in DNA synthesis and repair, transcription factors, and signaling proteins.
The thioredoxin system's activity is intimately linked to the cell's overall redox state, which is largely determined