stollingsprofiel

A stollingsprofiel, or coagulation profile, is a group of laboratory tests that assess the blood's ability to clot. It is used to detect, diagnose, and monitor various bleeding and clotting disorders. The profile typically includes several key tests.

Prothrombin time (PT) measures the time it takes for blood to clot using the extrinsic pathway of coagulation. It is often reported as an international normalized ratio (INR) to standardize results across different laboratories. Activated partial thromboplastin time (aPTT) measures the time it takes for blood to clot using the intrinsic pathway.

Fibrinogen levels indicate the amount of this essential clotting protein in the blood. Low levels can suggest an inability to form clots, while high levels may indicate an increased risk of clotting. Thrombin time (TT) assesses the final common pathway of coagulation, specifically the conversion of fibrinogen to fibrin.

A complete stollingsprofiel helps clinicians evaluate potential problems with any of the multiple steps involved in the clotting cascade. Abnormal results can point to deficiencies in clotting factors, the presence of inhibitors, or other underlying medical conditions affecting hemostasis. It is a vital tool in managing patients undergoing anticoagulant therapy, those with a history of unexplained bleeding or thrombosis, or individuals requiring pre-surgical evaluation.