siteleucinerich
Siteleucinerich is a term used in protein sequence analysis to denote regions in a protein where leucine residues occur with high frequency within a defined window. It highlights hydrophobic patches formed primarily by leucine and nearby hydrophobic amino acids. The concept is distinct from leucine-rich repeats, although both involve leucine-rich sequences.
Defining criteria vary by study, but common criteria involve a window size of 10–20 amino acids with
Functional considerations suggest that siteleucinerich regions can contribute to protein stability through hydrophobic packing, and they
Relationship to other motifs: siteleucinerich should not be confused with leucine-rich repeats (LRR) or leucine zipper