rs1800460

rs1800460 is a single nucleotide polymorphism (SNP) located in the promoter region of the dopamine D2 receptor gene (DRD2). This SNP is also known by several other names, including TaqI A, A1 allele, and C/T polymorphism. The rs1800460 SNP is characterized by a change from cytosine (C) to thymine (T) at a specific position. Individuals can have one of three genotypes: CC, CT, or TT.

Research has explored the potential association of rs1800460 with various traits and conditions. Some studies have suggested links to dopamine-related behaviors, including reward sensitivity, impulsivity, and addictive tendencies. Additionally, this SNP has been investigated in the context of neurological and psychiatric disorders such as Parkinson's disease, schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). However, findings across studies have not always been consistent, and the exact functional impact of this polymorphism on DRD2 receptor activity remains a subject of ongoing research. It is important to note that genetic associations do not imply direct causation, and many factors contribute to complex human behaviors and health outcomes.