reseptorkoblingen
Reseptorkoblingen, or receptor coupling, is the process by which cellular receptors translate extracellular signals into intracellular responses by engaging signaling proteins and enzymes. It encompasses the initial binding event as well as the downstream signaling cascades that alter cellular behavior.
Several receptor families employ distinct coupling mechanisms: G protein-coupled receptors (GPCRs) couple to heterotrimeric G proteins;
In GPCRs, ligand binding triggers a conformational change that promotes GDP-GTP exchange on the Gα subunit,
Regulation of reseptorkoblingen involves mechanisms that limit or reshape signaling. Desensitization by receptor kinases and beta-arrestins
Significance and applications: reseptorkoblingen is essential for sensory perception, neural communication, endocrine and immune signaling, development,
Therapeutic relevance: many drugs target receptor coupling processes, including beta-blockers, tyrosine kinase inhibitors, and monoclonal antibodies.