releasinghormoneja
Releasing hormones are hypothalamic peptides that regulate the secretion of hormones by the anterior pituitary gland. They are released into the hypothalamic-pituitary portal circulation and act on specific pituitary cells to elicit hormone release. The principal releasing hormones are thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), gonadotropin-releasing hormone (GnRH), and growth hormone-releasing hormone (GHRH). TRH stimulates the release of thyroid-stimulating hormone (TSH) and can enhance prolactin secretion. CRH triggers the release of adrenocorticotropic hormone (ACTH). GnRH drives the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). GHRH promotes the release of growth hormone (GH).
The hypothalamus also synthesizes inhibitory signals that modulate pituitary activity, notably dopamine, which inhibits prolactin release,
Regulation of releasing hormone secretion is pulsatile and influenced by neural input, circadian rhythms, stress, nutritional
Clinical relevance arises in disorders of the hypothalamic-pituitary axis. Analogs and antagonists of releasing hormones are