rLH
rLH stands for recombinant luteinizing hormone, a pharmaceutical form of the gonadotropin LH produced by recombinant DNA technology. It is manufactured in mammalian cells, most commonly Chinese hamster ovary (CHO) cells, resulting in a glycoprotein hormone that is structurally similar to endogenous LH. The drug is administered by subcutaneous injection and has a biological activity that binds LH receptors in target tissues.
In human females, LH acts on thecal cells to stimulate androgen production, which is aromatized in granulosa
In men with hypogonadotropic hypogonadism, rLH with rFSH can stimulate testosterone production and spermatogenesis.
Side effects are generally similar to other gonadotropins and may include injection-site reactions, headaches, nausea, and
Brand-name lutropin alfa is Luveris; several biosimilars are available in different regions.