progastrinreleasing
Progastrin‑releasing peptide (ProGRP) is an 31‑amino‑acid prohormone that is processed to generate activity in the nervous and gastrointestinal systems. It is a member of the gastrin‑releasing peptide family and is synthesized primarily by neuroendocrine cells throughout the body. The precursor is cleaved by prohormone convertases, producing the mature neuropeptide gastrin‑releasing peptide (GRP), which is a potent mitogen for gastric mucosa and modulates sensory signaling.
In addition to its physiological roles, ProGRP is used as a biomarker for neuroendocrine tumours, most notably
The gene encoding ProGRP, known as CHGA or preprogastrin‑releasing granule protein, is located on chromosome 19q13
Research has investigated the signaling pathways downstream of GRP receptor activation, including the phospholipase C/inositol triphosphate
Overall, ProGRP is a clinically relevant peptide that functions as both a biological mediator in the nervous