postynaptisella

Postynaptisella is a hypothetical postsynaptic macromolecular assembly proposed in theoretical models of synaptic organization. In these models, postynaptisella is envisioned as a modular complex anchored in the postsynaptic membrane that coordinates the clustering of neurotransmitter receptors with intracellular signaling and cytoskeletal elements. The term is not widely used in experimental neuroscience and has no confirmed molecular consensus.

Proposed components include scaffold proteins, receptor subunits such as glutamate receptors, adaptor molecules, and actin-associated proteins that collectively anchor receptors and shape nanodomains at the synapse. In the model, these components interact with canonical postsynaptic density proteins, enabling regulated receptor mobility and signal transduction.

Functionally, postynaptisella is posited to influence synaptic strength and plasticity by modulating receptor localization, trafficking, and signaling cascades in response to activity. It is intended to capture the integrated nature of postsynaptic architecture beyond individual receptors and connectors.

Status and reception: Because it remains hypothetical, postynaptisella is primarily discussed in conceptual discussions of synaptic organization rather than as an experimentally validated structure. Its usefulness lies in providing a framework to think about how diverse postsynaptic components coordinate to control synaptic efficacy.