peptideket
PeptideKet is a term encountered in peptide chemistry to describe peptides that bear a ketone functional group, enabling chemoselective ligation and labeling. The term is not universally standardized, and definitions vary across sources; in general it refers to peptides in which a ketone moiety is present either at the N-terminus as an amino ketone, at a side chain via a ketone-containing amino acid surrogate, or at the C-terminus through post-synthetic modification. PeptideKet constructs are typically prepared by incorporating a ketone-bearing amino acid analogue during solid-phase synthesis or by chemical modification after peptide assembly.
The ketone functionality in such peptides provides a reactive handle for bioconjugation. The most common reactions
Practical considerations include the stability of the ketone under synthesis and storage conditions, the potential for
See also: oxime ligation, hydrazone ligation, aminooxy compounds, peptide labeling. Note: 'PeptideKet' is a descriptive term